Amazon EC2 M8in and M8ib instances, powered by 6th-generation Intel Xeon Scalable processors and 6th-generation AWS Nitro cards, are now generally available alongside the memory-optimized R8in and R8ib variants. The new instances offer up to 43% higher performance compared to M6in and M6ib, with improved network throughput suited for I/O-intensive database tiers and large-scale data lake deployments. R8in and R8ib extend the same generational leap into memory-optimized territory, making them viable candidates for SAP HANA and other in-memory database engines. For data engineering teams running self-managed relational databases, columnar stores, or large Redis-compatible caches on EC2, this GA clears the path for migration from 6th-gen instances without waiting for preview access. Organizations targeting the highest-tier IOPS and network bandwidth profiles for database clusters should evaluate rightsizing against the new SKUs, as the per-instance cost-performance ratio shifts meaningfully at this generation boundary.